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      A comprehensive comparison study of three different planar IMRT QA techniques using MapCHECK 2

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          Abstract

          The purpose of this study is to determine comparability of three different planar IMRT QA techniques: patient gantry angle composite (PGAC), single gantry angle composite (SGAC), and field by field (FBF), using MapCHECK 2 device and the γ test as performance metrics; and to assess the dependency of these techniques on intensity modulation, couch attenuation, and detector position (angular dependency). Ten highly modulated head and neck (H&N) and ten moderately modulated prostate IMRT validation plans were delivered using different techniques and were intercompared using the Student's t‐test. The IMRT QA measurements were evaluated by percentage of points passing the γ test for three different criteria: 1% (dose difference)/1 mm (distance to agreement (DTA)) (C1), 2%/2 mm (C2), and 3%/3 mm (C3). To investigate dependency of the IMRT validation on treatment couch, ionization chamber measurements, as well as the conventional MapCHECK 2 QAs, were performed with PGAC and PGAC‐WOC (without couch; using an extended tennis racket‐type insert with negligible attenuation assumed). To determine angular dependency of the MapCHECK 2, patient gantry field‐by‐field (PG‐FBF) technique was delivered and evaluated separately for each field. The differences of γ passing rates between SGAC and FBF were statistically insignificant, while these were statistically significant when compared to PGAC. SGAC and FBF techniques showed statistically insignificant differences between different levels of intensity modulation (H&N vs. Prostate) at C2 and C3 criteria, while PGAC could not for any criteria. The treatment couch has a significant impact on γ passing rates (PGAC vs. PGAC‐WOC), but an ionization chamber‐based IMRT validations showed clinically insignificant dose errors (< 2%) in all cases. This study showed that the MapCHECK 2 device has large angular dependency, especially at gantry angles of 90° and 270°, which dramatically affected the γ passing rates of PGAC. With proper consideration of couch attenuation and beam arrangement, the MapCHECK 2 will produce clinically comparable QA results using the three different planar IMRT QA techniques.

          PACS numbers: 87.55.km, 87.55.Qr, 87.56.Fc

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          A technique for the quantitative evaluation of dose distributions.

          The commissioning of a three-dimensional treatment planning system requires comparisons of measured and calculated dose distributions. Techniques have been developed to facilitate quantitative comparisons, including superimposed isodoses, dose-difference, and distance-to-agreement (DTA) distributions. The criterion for acceptable calculation performance is generally defined as a tolerance of the dose and DTA in regions of low and high dose gradients, respectively. The dose difference and DTA distributions complement each other in their useful regions. A composite distribution has recently been developed that presents the dose difference in regions that fail both dose-difference and DTA comparison criteria. Although the composite distribution identifies locations where the calculation fails the preselected criteria, no numerical quality measure is provided for display or analysis. A technique is developed to unify dose distribution comparisons using the acceptance criteria. The measure of acceptability is the multidimensional distance between the measurement and calculation points in both the dose and the physical distance, scaled as a fraction of the acceptance criteria. In a space composed of dose and spatial coordinates, the acceptance criteria form an ellipsoid surface, the major axis scales of which are determined by individual acceptance criteria and the center of which is located at the measurement point in question. When the calculated dose distribution surface passes through the ellipsoid, the calculation passes the acceptance test for the measurement point. The minimum radial distance between the measurement point and the calculation points (expressed as a surface in the dose-distance space) is termed the gamma index. Regions where gamma > 1 correspond to locations where the calculation does not meet the acceptance criteria. The determination of gamma throughout the measured dose distribution provides a presentation that quantitatively indicates the calculation accuracy. Examples of a 6 MV beam penumbra are used to illustrate the gamma index.
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            IMRT commissioning: multiple institution planning and dosimetry comparisons, a report from AAPM Task Group 119.

            AAPM Task Group 119 has produced quantitative confidence limits as baseline expectation values for IMRT commissioning. A set of test cases was developed to assess the overall accuracy of planning and delivery of IMRT treatments. Each test uses contours of targets and avoidance structures drawn within rectangular phantoms. These tests were planned, delivered, measured, and analyzed by nine facilities using a variety of IMRT planning and delivery systems. Each facility had passed the Radiological Physics Center credentialing tests for IMRT. The agreement between the planned and measured doses was determined using ion chamber dosimetry in high and low dose regions, film dosimetry on coronal planes in the phantom with all fields delivered, and planar dosimetry for each field measured perpendicular to the central axis. The planar dose distributions were assessed using gamma criteria of 3%/3 mm. The mean values and standard deviations were used to develop confidence limits for the test results using the concept confidence limit = /mean/ + 1.96sigma. Other facilities can use the test protocol and results as a basis for comparison to this group. Locally derived confidence limits that substantially exceed these baseline values may indicate the need for improved IMRT commissioning.
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              On the insensitivity of single field planar dosimetry to IMRT inaccuracies.

              To report on the sensitivity of single field planar measurements in identifying IMRT plans with poor calculational accuracy. Three IMRT plans for head and neck cancer were subjected to extensive quality assurance. The plans were recalculated on a cylindrical phantom and between eight and 18 low gradient points were measured in each plan with an ion chamber. Every point measured in these plans agreed to within 4% of the dose predicted by the planning system and the plans were judged acceptable for clinical use. Each plan was then reoptimized with aggressive dose constraints so that the new treatment fields were more highly modulated than the ones from the original plans. Very complex fields can be calculated less accurately and ion chamber measurements of these plans in the cylindrical phantom confirmed significant dosimetric errors--Several of the measured points in each plan differed from the calculated dose by more than 4%, with a maximum single deviation of 10.6%. These three plans were judged unacceptable for clinical use. All six plans (three acceptable, three unacceptable) were then analyzed with two means of individual field planar dosimetry: Portal imaging with an electronic portal imaging device (EPID) and an ion chamber array. Gamma analysis was performed on each set of planar measurements with 2%/2 mm distance to agreement (DTA) and 3%/3 mm DTA criteria to try to determine a gamma analysis threshold which would differentiate the flawed plans from the acceptable ones. With the EPID and 2%/2 mm DTA criteria, between 88.2% and 92.8% of pixels from the acceptable IMRT plans passed the gamma analysis, and between 87.5% and 91.9% passed for the unacceptable IMRT plans. With the ion chamber array and 2%/2 mm DTA criteria, between 92.4% and 94.9% of points in the acceptable plans passed the gamma analysis, while 86.8% to 98.3% of the points in the unacceptable plans passed the gamma analysis. The difference between acceptable and unacceptable plans was diminished further when gamma criteria were expanded to 3%/3 mm DTA. A fraction of pixels passing the gamma analysis was found to be a poor predictor of dosimetric accuracy with both planar dosimeters, as well as both sets of gamma criteria. Deconstruction of an IMRT plan for field-by-field QA requires complex analysis methods such as the gamma function. Distance to agreement, a component of the gamma function, has clinical relevance in a composite plan but when applied to individual, highly modulated fields, it can mask important dosimetric errors. While single field planar dosimetry may comprise one facet of an effective QA protocol, gamma analysis of single field measurements is insensitive to important dosimetric inaccuracies of the overall plan.
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                Author and article information

                Contributors
                hosang-jin@ouhsc.edu
                Journal
                J Appl Clin Med Phys
                J Appl Clin Med Phys
                10.1002/(ISSN)1526-9914
                ACM2
                Journal of Applied Clinical Medical Physics
                John Wiley and Sons Inc. (Hoboken )
                1526-9914
                04 November 2013
                November 2013
                : 14
                : 6 ( doiID: 10.1002/acm2.2013.14.issue-6 )
                : 222-233
                Affiliations
                [ 1 ] Department of Radiation Oncology University of Oklahoma Health Sciences Center Oklahoma City OK USA
                Author notes
                [*] [* ] a Corresponding author: Hosang Jin, Department of Radiation Oncology, University of Oklahoma Health Sciences Center, 800 NE 10th Street, OKCC L100, Oklahoma City, OK 73104, USA; phone: (405) 271 3016; fax: (405) 271 8297; email: hosang-jin@ 123456ouhsc.edu

                Article
                ACM20222
                10.1120/jacmp.v14i6.4398
                5714623
                24257283
                c5121a93-f953-412c-9164-bbcecb972eae
                © 2013 The Authors.

                This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 01 February 2013
                : 05 July 2013
                Page count
                Figures: 5, Tables: 5, References: 19, Pages: 12, Words: 5878
                Categories
                Radiation Oncology Physics
                Radiation Oncology Physics
                Custom metadata
                2.0
                acm20222
                November 2013
                Converter:WILEY_ML3GV2_TO_NLMPMC version:5.2.5 mode:remove_FC converted:17.11.2017

                imrt quality assurance,mapcheck,angular dependency,varian igrt treatment couch,field by field

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