Communication during a crisis can affect crisis management and health outcomes. Only a few studies in Africa have examined political leaders’ speeches on Covid-19 pandemic preventive and restrictive lockdown measures. The purpose of this study is to examine the discourse strategies employed in President Nana Addo’s speeches delivered to Ghanaians on the measures taken to combat the coronavirus. The first ten speeches of Nana Addo since the inception of Covid-19 were selected, coded, and examined using content thematic analysis. The analysis of these speeches identified five main themes to capture the discourse strategies which President Nana Addo used. The strategies captured in the thematic analysis included framing Covid-19 as a war, encouraging nationalism and patriotism, showing appreciation and gratitude, threatening sanctions, and using religious values. These strategies were reinforced by using religious, moralizing, and national identity legitimation discourses to justify measures the government had put in place to minimize the impact of Covid-19 and improve healthcare response. Also, the historical, social, and political contexts of Ghana and elsewhere were invoked in Nana Addo’s speeches to legitimize the government’s response to Covid-19. In conclusion, we highlight the implications of these strategies on crisis communication and management.