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      The association between serum uric acid and blood pressure in different age groups in a healthy Chinese cohort

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          Abstract

          High serum uric acid (sUA) has been reported to be a risk factor for hypertension however, whether this is the case for all age groups is not clear. We examined the association between sUA concentrations and systolic and diastolic blood pressure (SBP and DBP) in different age groups in a cohort of healthy Chinese participants.

          A total of 1082 healthy participants aged from 41 to 70 years were included. sUA concentration was measured by the uricase-peroxidase method. SBP and DBP were assessed using mercury sphygmomanometry. Hypertension was defined as SBP ≥140 mm Hg or DBP ≥90 mm Hg. Hyperuricemia (HUA) was defined as sUA concentration of >7 mg/dL in men and >6 mg/dL in women. The association between sUA concentration and SBP and DBP was examined using Pearson's correlation test, multivariate linear regression, and logistic regression analysis.

          The prevalence of hypertension and HUA increased with age ( P < .001). Hypertension was more common in participants that had HUA than in those that did not (38.95% vs 30.16%, P = .02). Higher sUA was significantly associated with higher SBP and DBP in the 41- to 50-year-old participants (SBP, β = 0.35, P < .001; DBP, β = .29, P < .001; after adjustment for age, sex, total cholesterol, estimated glomerular filtration rate, and fasting plasma glucose). HUA was also a risk factor for hypertension in this age group (odds ratio 1.425, 95% confidence interval, 1.217–1.668, P < .001). There was no association between sUA concentration and SBP and DBP in the other age groups.

          In this population of healthy Chinese participants, sUA concentration was positively associated with hypertension only in the 41- to 50-year-old group. Lowering uric acid in this age group may help to reduce the incidence of hypertension.

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          Most cited references29

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          Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study.

          Hyperuricemia is associated with risk for cardiovascular disease and death. However, the role of uric acid independent of established risk factors is uncertain. To examine the relation of serum uric acid level to incident coronary heart disease, death from cardiovascular disease, and death from all causes. Community-based, prospective observational study. Framingham, Massachusetts. 6763 Framingham Heart Study participants (mean age, 47 years). Serum uricacid level at baseline (1971 to 1976); event rates per 1000 person-years by sex-specific uric acid quintile. During 117,376 person-years of follow-up, 617 coronary heart disease events, 429 cardiovascular disease deaths, and 1460 deaths from all causes occurred. In men, after adjustment for age, elevated serum uric acid level was not associated with increased risk for an adverse outcome. In women, after adjustment for age, uric acid level was predictive of coronary heart disease (P = 0.002), death from cardiovascular disease (P = 0.009), and death from all causes (P = 0.03). After additional adjustment for cardiovascular disease risk factors, uric acid level was no longer associated with coronary heart disease, death from cardiovascular disease, or death from all causes. In a stepwise Cox model, diuretic use was identified as the covariate responsible for rendering serum uric acid a statistically nonsignificant predictor of outcomes. These findings indicate that uric acid does not have a causal role in the development of coronary heart disease, death from cardiovascular disease, or death from all causes. Any apparent association with these outcomes is probably due to the association of uric acid level with other risk factors.
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            Prevalence of Hypertension in Low- and Middle-Income Countries

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              Prevalence of and trends in dyslipidemia and blood pressure among US children and adolescents, 1999-2012.

              Recent national data suggest there were improvements in serum lipid concentrations among US children and adolescents between 1988 and 2010 but an increase in or stable blood pressure (BP) during a similar period.
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                Author and article information

                Journal
                Medicine (Baltimore)
                Medicine (Baltimore)
                MEDI
                Medicine
                Wolters Kluwer Health
                0025-7974
                1536-5964
                December 2017
                15 December 2017
                : 96
                : 50
                : e8953
                Affiliations
                [a ]Department of Geriatric Cardiology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong Province, China
                [b ]Biomedical Science School of Applied and Biomedical Sciences, Federation University Australia, Mt Helen, Victoria, Australia
                [c ]Department of Cardiology, Ganzi Autonomous Prefecture Hospital, Kangding, Sichuan Province, China
                [d ]The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia
                [e ]Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Queensland, Australia.
                Author notes
                []Correspondence: Guang Yang, Department of Geriatric Cardiology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong Province, China (e-mail: yangg1972@ 123456126.com ).
                Article
                MD-D-17-03273 08953
                10.1097/MD.0000000000008953
                5815699
                29390287
                c5271573-6e85-49e2-aad0-8d07bb7dee95
                Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc.

                This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0

                History
                : 26 May 2017
                : 7 November 2017
                : 8 November 2017
                Categories
                3400
                Research Article
                Observational Study
                Custom metadata
                TRUE

                serum uric acid,hyperuricemia,blood pressure,hypertension

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