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      Constituents of the flowers of Erigeron annuus with inhibitory activity on the formation of advanced glycation end products (AGEs) and aldose reductase.

      Archives of Pharmacal Research

      Aldehyde Reductase, antagonists & inhibitors, biosynthesis, Animals, Enzyme Inhibitors, isolation & purification, pharmacology, Erigeron, chemistry, Flowers, Glycosylation End Products, Advanced, Magnetic Resonance Spectroscopy, Plant Extracts, Rats, Rats, Sprague-Dawley, Solvents, Spectrometry, Mass, Electrospray Ionization, Spectroscopy, Fourier Transform Infrared

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          Abstract

          Seven phenolic compounds, caffeic acid (1), 4-hydroxybenzoic acid (2), 4-methoxybenzoic acid (3), protocatechuic acid (4), eugenol O-beta-D: -glucopyranoside (5), 3,6-di-O-feruloylsucrose (6), and 3,5-di-O-caffeoylquinic acid methyl ester (7), were isolated from an EtOAc-soluble partition of the flowers of Erigeron annuus. The structures of 1-7 were determined by spectroscopic data interpretation, particularly 1D and 2D NMR studies, and by comparison of their data with those published in the literature. All the isolates were subjected to in vitro bioassays to evaluate their inhibitory activities against the formation of advanced glycation end products (AGEs) and rat lens aldose reductase (RLAR). Of the compounds, 1, 6, and 7 exhibited potent inhibitory activities against the formation of AGEs. In the RLAR assay, compound 7 showed the most potent inhibitory activity.

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          Journal
          18704333
          10.1007/s12272-001-1244-z

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