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Different effects of pravastatin and cerivastatin on the media of the carotid arteries as assessed by integrated backscatter ultrasound.
Yoko Ito
1 ,
Masanori Kawasaki ,
Haruko Yokoyama ,
Munenori Okubo ,
Keiji Sano ,
Masazumi Arai ,
Kazuhiko Nishigaki ,
Yoshihiro Uno ,
Genzou Takemura ,
Shinya Minatoguchi ,
Hisayoshi Fujiwara
Aug 2004
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Abstract
Currently, there are various types of statins used in the treatment of hyperlipidemia and coronary artery disease. The purpose of this study was to compare the effects of a lipophilic statin (cerivastatin) with those of a hydrophilic statin (pravastatin) on the carotid arterial media using integrated backscatter (IB) ultrasound. Cerivastatin (C) has a strong anti-proliferative effect (APE) on smooth muscle cells (SMCs), whereas pravastatin (P) has a weak effect.