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The conical glass nanopore was modified through layer-by-layer electrostatic deposition
of a monolayer of glucose oxidase, and then an ultrathin gold film was formed in situ
through enzyme-catalyzed reactions. The morphology and components of single glass
nanopore before and after ultrathin Au deposition were characterized by transmission
electron microscopy (TEM) and energy-dispersive X-ray (EDX) analysis, respectively.
In particular, the quenching of the quantum dots fluorescence in the nanopore tip
zone further illustrated that the gold nanofilm was successfully deposited on the
inner wall of the single glass nanopore. The Au thin films make the glass nanopores
more biologically friendly and allow the nanopores facile functionalization of the
surface through the Au-S bonds. For instance, the ionic current rectification (ICR)
properties of the gold-decorated glass nanopores could be switched readily at different
pHs by introducing different thiol molecules.