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      From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers

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          Abstract

          The molecular complexity and heterogeneity of cancer has led to a persistent, and as yet unsolved, challenge to develop cures for this disease. The pharmaceutical industry focuses the bulk of its efforts on the development of new drugs, but an alternative approach is to improve the delivery of existing drugs with drug carriers that can manipulate when, where, and how a drug exerts its therapeutic effect. For the treatment of solid tumors, systemically delivered drug carriers face significant challenges that are imposed by the pathophysiological barriers that lie between their site of administration and their site of therapeutic action in the tumor. Furthermore, drug carriers face additional challenges in their translation from preclinical validation to clinical approval and adoption. Addressing this diverse network of challenges requires a systems engineering approach for the rational design of optimized carriers that have a realistic prospect for translation from the laboratory to the patient.

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          Author and article information

          Journal
          0370543
          537
          Angew Chem Int Ed Engl
          Angew. Chem. Int. Ed. Engl.
          Angewandte Chemie (International ed. in English)
          1433-7851
          1521-3773
          7 February 2019
          02 May 2017
          06 June 2017
          12 February 2019
          : 56
          : 24
          : 6712-6733
          Affiliations
          Department of Biomedical Engineering, Duke University, P.O. Box 90281, Durham, NC 27708 (USA)
          Research Triangle MRSEC, Durham, NC 27708 (USA)
          Author notes

          Present address: S. R. MacEwan, Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637 (USA)

          Article
          PMC6372097 PMC6372097 6372097 nihpa1010379
          10.1002/anie.201610819
          6372097
          28028871
          c555f87f-a4e4-4b6a-b4c6-a5f2470ab911
          History
          Categories
          Article

          antitumor drugs,nanoparticles,drug delivery,cancer
          antitumor drugs, nanoparticles, drug delivery, cancer

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