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huckebein is required for glial development and axon pathfinding in the neuroblast 1-1 and neuroblast 2-2 lineages in the Drosophila central nervous system
March 1996
March 1996
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Abstract
huckebein encodes a predicted zinc finger transcription factor which is transiently
expressed in a subset of Drosophila central nervous system precursors (neuroblasts
(NBs)). We used DiI cell lineage tracing and cell fate markers to investigate the
role of huckebein in the NB 1-1 and NB 2-2 cell lineages. Loss of huckebein does not
switch these NBs into different NB fates, nor does it change the number of cells in
their lineages; rather, it is required for glial development in the NB 1-1 lineage,
and for axon pathfinding of a subset of interneurons and motoneurons in both lineages.