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      The Status and Impact of Clinical Tumor Genome Sequencing

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      Annual Review of Genomics and Human Genetics

      Annual Reviews

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          Abstract

          Since the discovery that DNA alterations initiate tumorigenesis, scientists and clinicians have been exploring ways to counter these changes with targeted therapeutics. The sequencing of tumor DNA was initially limited to highly actionable hot spots—areas of the genome that are frequently altered and have an approved matched therapy in a specific tumor type. Large-scale genome sequencing programs quickly developed technological improvements that enabled the deployment of whole-exome and whole-genome sequencing technologies at scale for pristine sample materials in research environments. However, the turning point for precision medicine in oncology was the innovations in clinical laboratories that improved turnaround time, depth of coverage, and the ability to reliably sequence archived, clinically available samples. Today, tumor genome sequencing no longer suffers from significant technical or financial hurdles, and the next opportunity for improvement lies in the optimal utilization of the technologies and data for many different tumor types.

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          Author and article information

          Journal
          Annual Review of Genomics and Human Genetics
          Annu. Rev. Genom. Hum. Genet.
          Annual Reviews
          1527-8204
          1545-293X
          April 17 2019
          August 30 2019
          April 17 2019
          August 30 2019
          : 20
          : 1
          Affiliations
          [1 ]Khalifa Bin Zayed Institute for Personalized Cancer Therapy and Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA;
          Article
          10.1146/annurev-genom-083118-015034
          © 2019

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