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Whole-genome landscape of pancreatic neuroendocrine tumours
Aldo Scarpa ,
David K. Chang ,
Katia Nones ,
Vincenzo Corbo ,
Ann-Marie Patch ,
Peter Bailey ,
Rita T. Lawlor ,
Amber L. Johns ,
David K. Miller ,
Andrea Mafficini ,
Borislav Rusev ,
Maria Scardoni ,
Davide Antonello ,
Stefano Barbi ,
Katarzyna O. Sikora ,
Sara Cingarlini ,
Caterina Vicentini ,
Skye McKay ,
Michael C. J. Quinn ,
Timothy J. C. Bruxner ,
Angelika N. Christ ,
Ivon Harliwong ,
Senel Idrisoglu ,
Suzanne McLean ,
Craig Nourse ,
Ehsan Nourbakhsh ,
Peter J. Wilson ,
Matthew J. Anderson ,
J. Lynn Fink ,
Felicity Newell ,
Nick Waddell ,
Oliver Holmes ,
Stephen H. Kazakoff ,
Conrad Leonard ,
Scott Wood ,
Qinying Xu ,
Shivashankar Hiriyur Nagaraj ,
Eliana Amato ,
Irene Dalai ,
Samantha Bersani ,
Ivana Cataldo ,
Angelo P. Dei Tos ,
Paola Capelli ,
Maria Vittoria Davì ,
Luca Landoni ,
Anna Malpaga ,
Marco Miotto ,
Vicki L. J. Whitehall ,
Barbara A. Leggett ,
Janelle L. Harris ,
Jonathan Harris ,
Marc D. Jones ,
Jeremy Humphris ,
Lorraine A. Chantrill ,
Venessa Chin ,
Adnan M. Nagrial ,
Marina Pajic ,
Christopher J. Scarlett ,
Andreia Pinho ,
Ilse Rooman ,
Christopher Toon ,
Jianmin Wu ,
Mark Pinese ,
Mark Cowley ,
Andrew Barbour ,
Amanda Mawson ,
Emily S. Humphrey ,
Emily K. Colvin ,
Angela Chou ,
Jessica A. Lovell ,
Nigel B. Jamieson ,
Fraser Duthie ,
Marie-Claude Gingras ,
William E. Fisher ,
Rebecca A. Dagg ,
Loretta M. S. Lau ,
Michael Lee ,
Hilda A. Pickett ,
Roger R. Reddel ,
Jaswinder S. Samra ,
James G. Kench ,
Neil D. Merrett ,
Krishna Epari ,
Nam Q. Nguyen ,
Nikolajs Zeps ,
Massimo Falconi ,
Michele Simbolo ,
Giovanni Butturini ,
George Van Buren ,
Stefano Partelli ,
Matteo Fassan ,
Kum Kum Khanna ,
Anthony J. Gill ,
David A. Wheeler ,
Richard A. Gibbs ,
Elizabeth A. Musgrove ,
Claudio Bassi ,
Giampaolo Tortora ,
Paolo Pederzoli ,
John V. Pearson ,
Nicola Waddell ,
Andrew V. Biankin ,
Sean M. Grimmond
February 15 2017
February 15 2017
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Abstract
The genomes of 102 primary pancreatic neuroendocrine tumours have been sequenced, revealing mutations in genes with functions such as chromatin remodelling, DNA damage repair, mTOR activation and telomere maintenance, and a greater-than-expected contribution from germ line mutations.