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Bath-water compared with oral delivery of 8-methoxypsoralen PUVA therapy for chronic plaque psoriasis.

Author(s): Jennifer J. P. Collins, Erin S Rogers

Publication date: 1992-09-30

Journal: The British Journal of Dermatology

Keywords: Administration, Oral, Administration, Topical, Adolescent, Adult, Baths, Chronic Disease, Female, Humans, Male, Methoxsalen, administration & dosage, Middle Aged, PUVA Therapy, methods, Psoriasis, drug therapy, Severity of Illness Index, Single-Blind Method

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Abstract

Forty-four patients with chronic plaque psoriasis were randomly allocated to treatment with bath-water-delivered 8-methoxypsoralen (bath 8-MOP) or oral 8-methoxypsoralen (oral 8-MOP) PUVA therapy. There was a significant reduction in extent of the lesions and psoriasis area and severity index (PASI) after 20 treatments with each modality. There was a fourfold reduction in cumulative ultraviolet A (UVA) dose in the bath group. Side-effects of erythema and nausea were less with bath therapy.

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PubMed ID:: 1419760

ScienceOpen disciplines: Chemistry

Keywords: Administration, Oral,Administration, Topical,Adolescent,Adult,Baths,Chronic Disease,Female,Humans,Male,Methoxsalen,administration & dosage,Middle Aged,PUVA Therapy,methods,Psoriasis,drug therapy,Severity of Illness Index,Single-Blind Method

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ScienceOpen disciplines: Chemistry

Bath-water compared with oral delivery of 8-methoxypsoralen PUVA therapy for chronic plaque psoriasis.

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