Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine.

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Abstract

Elevated levels of plasma trimethylamine N-oxide (TMAO), the product of gut microbiome and hepatic-mediated metabolism of dietary choline and L-carnitine, have recently been identified as a novel risk factor for the development of atherosclerosis in mice and humans. The goal of this study was to identify the genetic factors associated with plasma TMAO levels.

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Author and article information

Journal

Journal ID (iso-abbrev): Arterioscler. Thromb. Vasc. Biol.

Title: Arteriosclerosis, thrombosis, and vascular biology

ISSN (Electronic): 1524-4636

ISSN (Print): 1079-5642

Publication date (Electronic): Jun 2014

Volume: 34

Issue: 6

Affiliations

[1 ] From the Department of Preventive Medicine (J.H., H.A.) and Institute for Genetic Medicine (J.H., H.A.), Keck School of Medicine of the University of Southern California, Los Angeles; Department of Genetics (B.J.B.) and Nutrition Research Institute (B.J.B.), University of North Carolina, Chapel Hill, Kannapolis; Departments of Cardiovascular Medicine (W.H.W.T., Z.W., S.L.H.) and Cellular and Molecular Medicine (W.H.W.T., Z.W., S.L.H.) and Center for Cardiovascular Diagnostics and Prevention (W.H.W.T., Z.W., S.L.H.), Cleveland Clinic, OH; John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (A.F.R.S., R.R., R.M.); and Departments of Medicine (A.J.L.), Human Genetics (A.J.L.), and Microbiology, Immunology, and Molecular Genetics (A.J.L.), David Geffen School of Medicine of UCLA.

[2 ] From the Department of Preventive Medicine (J.H., H.A.) and Institute for Genetic Medicine (J.H., H.A.), Keck School of Medicine of the University of Southern California, Los Angeles; Department of Genetics (B.J.B.) and Nutrition Research Institute (B.J.B.), University of North Carolina, Chapel Hill, Kannapolis; Departments of Cardiovascular Medicine (W.H.W.T., Z.W., S.L.H.) and Cellular and Molecular Medicine (W.H.W.T., Z.W., S.L.H.) and Center for Cardiovascular Diagnostics and Prevention (W.H.W.T., Z.W., S.L.H.), Cleveland Clinic, OH; John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (A.F.R.S., R.R., R.M.); and Departments of Medicine (A.J.L.), Human Genetics (A.J.L.), and Microbiology, Immunology, and Molecular Genetics (A.J.L.), David Geffen School of Medicine of UCLA. hallayee@usc.edu.

Article

Publisher Item ID: ATVBAHA.114.303252 Mid ID: NIHMS578157

DOI: 10.1161/ATVBAHA.114.303252

PMC ID: 4035110

PubMed ID: 24675659

SO-VID: c5959205-cb46-4ea1-89de-442cd3e03f9d

History

Keywords: atherosclerosis,genetics,humans,mice,trimethylamine N-oxide

Data availability:

Keywords: atherosclerosis, genetics, humans, mice, trimethylamine N-oxide

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