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      Association between inflammation and immunity with child autism spectrum disorder based on CiteSpace analysis


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          Objective To summarize recent progress in the inflammation and immunity research on autism spectrum disorder (ASD) in children during 2002 to 2021, and to provide future directions.

          Methods Literature review was conducted in May 2022, with the literature source of core collection of the Web of Science database. CiteSpace software was used for bibliometric analysis. A total of 4 458 literature was included.

          Results In the past decade, the number of published articles increased rapidly, from 52 to 528. American has produced the highest number of articles ( n = 2 016), followed by China with 407 papers published. The high-frequency words included autism spectrum disorder, children, brain, autism, spectrum disorder. The high centrality keywords included schizophrenia, central nervous system, mental regression, multiple sclerosis, autoantibody. Recent researches in ASD primarily focused on the following three aspects: core symptoms and brain mechanism, gene-environment interaction, and epidemiological research. Maternal immune activation and gut-brain axis were gradually becoming research hotspots.

          Conclusion Research on inflammation and immunity of ASD in children increased rapidly in the past 20 years. Recent research hotspots included maternal immune activation and gut brain axis mechanisms, which could be integreted in future efforts to develop prevention and intervention programming on ASD in children.


          【摘要】 目的 对2002—2021年孤独症谱系障碍(autism spectrum disorder, ASD)炎症与免疫方面研究进行文献计量分 析, 为炎症与免疫因素在儿童ASD发病机制中研究提供参考。 方法 2022年5月以Web of Science数据库核心合集为文 献来源, 使用CiteSpace软件进行分析, 最终纳入文献4 458篇。 结果 2002—2021年发文量迅速增加, 由52篇增加至528 篇。美国发文量最高, 为2 016篇; 中国次之, 为407篇。高频词依次为autism spectrum disorder, children, brain, autism, spectrum disorder 等, 高中心性关键词依次为 schizophrenia, central nervous system, mental retardation, multiple sclerosis, autoantibody 等。研究趋势与热点分析表明, 研究内容主要集中在核心症状及脑机制研究、基因与环境交互作用研究、流行病学研究3 个方面, 而母体免疫激活与肠脑轴逐渐成为研究热点。 结论 ASD炎症与免疫研究在近20年发展较为迅速, 近期研究热 点主要集中在母体免疫激活与肠脑轴等致病机制方面。中国应加大相关研究力度, 为儿童ASD预防、干预和治疗提供科 学依据。

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          Author and article information

          Chinese Journal of School Health
          Chinese Journal of School Health (China )
          01 December 2022
          01 January 2023
          : 43
          : 12
          : 1843-1846
          [1] 1Department of Maternal, Child and Adolescence Health, School of Public Health, Tianjin Medical University, Tianjin (300070), China
          Author notes
          *Corresponding author: ZHANG Xin, E-mail: zhangxin@ 123456tmu.edu.cn
          © 2022 Chinese Journal of School Health

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

          Self URI (journal-page): http://www.cjsh.org.cn
          Journal Article

          Ophthalmology & Optometry,Pediatrics,Nutrition & Dietetics,Clinical Psychology & Psychiatry,Public health
          Autistic disorder,Child,Inflammation,Mental health,Immunity


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