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      In vitro Production of ‘Glomerular Red Cells’: Role of pH and Osmolality

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      Nephron

      S. Karger AG

      Glomerular red cells, Filtration, pH, Osmolality

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          Abstract

          We used an in vitro model consisting of a polycarbonate filter with pore diameters of 3 μm, through which red cells suspended in urine or buffer were pumped at a flow rate of 0.5 ml/min. pH and osmolality of the suspension were systematically changed within a range of pH 5–8 and 200–800 mosm/kg H<sub>2</sub>O. It was found that: (1) glomerular shapes could be produced by this filtration technique; (2) urine facilitated the production of glomerular shapes; (3) certain shapes occurred predominantly, at specific conditions of pH and osmolality and (4) hemolysis decreased with increasing osmolality or very low pH. These observations shed light on the mechanism by which glomerular red cell shapes are formed.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1990
          1990
          10 December 2008
          : 56
          : 1
          : 13-18
          Affiliations
          Department of Internal Medicine, University of Berne, Inselspital Berne, Switzerland
          Article
          186093 Nephron 1990;56:13–18
          10.1159/000186093
          2234244
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Filtration, Glomerular red cells, pH, Osmolality

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