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      Stress, memory and the amygdala.

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          Abstract

          Emotionally significant experiences tend to be well remembered, and the amygdala has a pivotal role in this process. But the efficient encoding of emotional memories can become maladaptive - severe stress often turns them into a source of chronic anxiety. Here, we review studies that have identified neural correlates of stress-induced modulation of amygdala structure and function - from cellular mechanisms to their behavioural consequences. The unique features of stress-induced plasticity in the amygdala, in association with changes in other brain regions, could have long-term consequences for cognitive performance and pathological anxiety exhibited in people with affective disorders.

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          Author and article information

          Journal
          Nat Rev Neurosci
          Nature reviews. Neuroscience
          Springer Science and Business Media LLC
          1471-0048
          1471-003X
          Jun 2009
          : 10
          : 6
          Affiliations
          [1 ] Department of Neuroscience, University Medical Center Groningen, University of Groningen, the Netherlands. b.roozendaal@med.umcg.nl
          Article
          10.1038/nrn2651
          19469026
          c5ebe13d-3abc-4762-a02d-da1d0de19067

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