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      The cellular and molecular response of cardiac myocytes to mechanical stress.

      Annual review of physiology
      Animals, Cardiomegaly, etiology, Growth Substances, physiology, Humans, Mechanoreceptors, Myocardium, metabolism, pathology, Signal Transduction, Stress, Mechanical

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          Abstract

          External load plays a critical role in determining muscle mass and its phenotype in cardiac myocytes. Cardiac myocytes have the ability to sense mechanical stretch and convert it into intracellular growth signals, which lead to hypertrophy. Mechanical stretch of cardiac myocytes in vitro causes activation of multiple second messenger systems that are very similar to growth factor-induced cell signaling systems. Stretch of neonatal rat cardiac myocytes stimulates a rapid secretion of angiotensin II which, together with other growth factors, mediates stretch-induced hypertrophic responses in vitro. In this review, various cell signaling mechanisms initiated by mechanical stress on cardiac myocytes are summarized with emphasis on potential mechanosensing mechanisms and the relationship between mechanical loading and the cardiac renin-angiotensin system.

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          Author and article information

          Journal
          9074777
          10.1146/annurev.physiol.59.1.551

          Chemistry
          Animals,Cardiomegaly,etiology,Growth Substances,physiology,Humans,Mechanoreceptors,Myocardium,metabolism,pathology,Signal Transduction,Stress, Mechanical

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