13
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Parámetros hematológicos del roedor subterráneo Spalacopus cyanus (Rodentia: Octodontidae) Translated title: Hematological parameters of subterranean rodent Spalacopus cyanus (Rodentia: Octodontidae)

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Resumen Describimos los parámetros hematológicos del roedor subterráneo endémico de Chile Spalacopus cyanus (Rodentia, Octodontidae). Nuestros resultados indican que presenta una condición hematológica que difiere en los altos valores de Hb por eritrocito (HCM) encontrados en roedores de hábitos típicamente subterráneos, donde su HCM representa 49.9 y 47.2% de lo informado para Ctenomys talarum y Ctenomys australis. Sin embargo, S. cyanus presenta algunas características hematológicas que incrementarían su capacidad de transporte de oxígeno en la sangre, tales como un elevado número de glóbulos rojos y un reducido tamaño de éstos. Aunque nuestros resultados contribuyen a la comprensión de los atributos que explican el uso del ecotopo subterráneo por esta especie, se requieren estudios que informen sobre las condiciones atmosféricas de sus galerías, el efecto del tipo de suelo sobre estas últimas, afinidad del O2 por la hemoglobina (efecto del 2.3 DPG) y los niveles de expresión de los genes EPO y HIF-1α bajo normoxia e hipoxia.

          Translated abstract

          Abstract Herein we describe the hematological parameters of the subterranean endemic Chilean rodent Spalacopus cyanus (Rodentia, Octodontidae). Our results show that it presents a distinctive hematological condition as it does not show the high values of hemoglobin per erythrocyt (HCM) found in other mainly subterranean rodents where the reported HCM values represent 49.9 and 47.2% for Ctenomys talarum and Ctenomys australis respectively. Nevertheless, S. cyanus presents some hematological characteristics that increase the oxygen transport capacity in blood as a large amount of red blood cells of small size. Even though our results help to understand the attributes that explain the use of the subterranean ecotope by this species other studies such as the atmospheric conditions in the galleries, the effects of the soil type on the latter the O2-affinity of the hemoglobin (2.3-DPG-effect) or the levels of gene expression of EPO and HIF-1α under normoxia and hypoxia are still required.

          Related collections

          Most cited references24

          • Record: found
          • Abstract: found
          • Article: not found

          Hypoxic stress tolerance of the blind subterranean mole rat: expression of erythropoietin and hypoxia-inducible factor 1 alpha.

          Blind subterranean mole rats (Spalax, Spalacidae) evolved adaptive strategies to cope with hypoxia that climaxes during winter floods in their burrows. By using real-time PCR, we compared gene expression of erythropoietin (Epo), a key regulator of circulating erythrocytes, and hypoxia-inducible factor 1 alpha (HIF-1 alpha), Epo expression inducer, in the kidneys of Spalax and white rats, Rattus norvegicus. Our results show significantly higher, quicker, and longer responses to different O(2) levels in Spalax compared with Rattus. (i) In normoxia, both Spalax and Rattus kidneys produce small amounts of Epo. Maximal expression of Rattus Epo is noticed after a 4-h hypoxia at 6% O(2). Under these conditions, Spalax Epo levels are 3-fold higher than in Rattus. After 24 h of 10% O(2), Spalax Epo reaches its maximal expression, remarkably 6-fold higher than the maximum in Rattus; (ii) the HIF-1 alpha level in normoxia is 2-fold higher in Spalax than in Rattus. Spalax HIF-1 alpha achieves maximal expression after 4-h hypoxia at 3% O(2), a 2-fold increase compared with normoxia, whereas no significant change was detected in Rattus HIF-1 alpha at any of the conditions studied; (iii) at 6% O(2) for 10 h, in which Rattus cannot survive, Epo and HIF-1 alpha levels in Spalax galili, living in heavily flooded soils, are higher than in Spalax judaei, residing in light aerated soil. We suggest that this pattern of Epo and HIF-1 alpha expression is a substantial contribution to the adaptive strategy of hypoxia tolerance in Spalax, evolved during 40 million years of evolution to cope with underground hypoxic stress.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Oxygen and carbon dioxide fluctuations in burrows of subterranean blind mole rats indicate tolerance to hypoxic-hypercapnic stresses.

            The composition of oxygen (O2), carbon dioxide (CO2), and soil humidity in the underground burrows from three species of the Israeli subterranean mole rat Spalax ehrenbergi superspecies were studied in their natural habitat. Two geographically close populations of each species from contrasting soil types were probed. Maximal CO2 levels (6.1%) and minimal O2 levels (7.2%) were recorded in northern Israel in the breeding mounds of S. carmeli in a flooded, poor drained field of heavy clay soil with very high volumetric water content. The patterns of gas fluctuations during the measurement period among the different Spalax species studied were similar. The more significant differentiation in gas levels was not among species, but between neighboring populations inhabiting heavy soils or light soils: O2 was lower and CO2 was higher in the heavy soils (clay and basaltic) compared to the relatively light soils (terra rossa and rendzina). The extreme values of gas concentration, which occurred during the rainy season, seemed to fluctuate with partial flooding of the tunnels, animal digging activity, and over-crowded breeding mounds inhabited by a nursing female and her offspring. The gas composition and soil water content in neighboring sites with different soil types indicated large differences in the levels of hypoxic-hypercapnic stress in different populations of the same species. A growing number of genes associated with hypoxic stress have been shown to exhibit structural and functional differences between the subterranean Spalax and the above-ground rat (Rattus norvegicus), probably reflecting the molecular adaptations that Spalax went through during 40 million years of evolution to survive efficiently in the severe fluctuations in gas composition in the underground habitat.
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              The atmospheric environment of the fossorial mole rat (Spalax ehrenbergi): Effects of season, soil texture, rain, temperature and activity

              R Arieli (1979)
                Bookmark

                Author and article information

                Journal
                rmbiodiv
                Revista mexicana de biodiversidad
                Rev. Mex. Biodiv.
                Instituto de Biología (México, DF, Mexico )
                1870-3453
                2007-8706
                2019
                : 90
                : e902743
                Affiliations
                [2] La Serena Coquimbo orgnameUniversidad de La Serena orgdiv1Facultad de Ciencias orgdiv2Departamento de Biología Chile
                [1] Copiapó Atacama orgnameUniversidad de Atacama orgdiv1Facultad de Ciencias orgdiv2Departamento de Química y Biología Chile
                Article
                S1870-34532019000100614 S1870-3453(19)09000000614
                10.22201/ib.20078706e.2019.90.2743
                c5feab85-8255-4d2d-abaa-e76bfd7e546d

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

                History
                : 08 March 2019
                : 19 June 2018
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 35, Pages: 0
                Product

                SciELO Mexico

                Categories
                Ecología

                Hemoglobina corpuscular media (HCM),Hemoglobin,Hemoglobina,Mean corpuscular volume (MCV),Volumen corpuscular medio (VCM),Red blood cell,Subterráneo,Spalacopus cyanus,Subterranean,Glóbulo rojo,Mean corpuscular hemoglobin (MCH)

                Comments

                Comment on this article