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      Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

      1 , 1
      Annual Review of Pharmacology and Toxicology
      Annual Reviews

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          Abstract

          The metabotropic glutamate receptors (mGluRs) are family C G-protein-coupled receptors that participate in the modulation of synaptic transmission and neuronal excitability throughout the central nervous system. The mGluRs bind glutamate within a large extracellular domain and transmit signals through the receptor protein to intracellular signaling partners. A great deal of progress has been made in determining the mechanisms by which mGluRs are activated, proteins with which they interact, and orthosteric and allosteric ligands that can modulate receptor activity. The widespread expression of mGluRs makes these receptors particularly attractive drug targets, and recent studies continue to validate the therapeutic utility of mGluR ligands in neurological and psychiatric disorders such as Alzheimer's disease, Parkinson's disease, anxiety, depression, and schizophrenia.

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          Author and article information

          Journal
          Annual Review of Pharmacology and Toxicology
          Annu. Rev. Pharmacol. Toxicol.
          Annual Reviews
          0362-1642
          1545-4304
          February 2010
          February 2010
          : 50
          : 1
          : 295-322
          Affiliations
          [1 ]Vanderbilt Program in Drug Discovery and Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37212; email: ,
          Article
          10.1146/annurev.pharmtox.011008.145533
          2904507
          20055706
          c5ff50c2-e7c6-4ad7-a915-b949b5fa8161
          © 2010
          History

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