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      Growth Hormone and Growth Factors during Perinatal Life

      Hormone Research in Paediatrics

      S. Karger AG

      Growth hormone, Insulin-like growth factor, Perinatal life, Fetus, Growth

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          Abstract

          Pituitary growth hormone (GH) is present in early pregnancy in the fetal circulation. The concentrations are higher than ever found during life, due to an unrestrained, basal secretion. GH receptors develop around midpregnancy, when they are present in low concentrations, and there is a rapid increase during the first months of life. The function of fetal GH – characterized by a nearly complete GH resistance – is largely unclear: there is only a small effect on longitudinal growth, and the regulation of growth factors is independent of GH. Possibly, metabolic effects of GH on fat and glucose metabolism and body composition are of greater importance. During the first months of life, the rapid fetal (GH-independent, nutrition-dependent) growth decelerates, a process that is partly compensated by the onset of GH-dependent longitudinal growth.

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          Most cited references 6

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          Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.

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            Clinical review 68: The endocrine regulation of fetal growth in late gestation: the role of insulin-like growth factors

             P. Gluckman (1995)
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              Spontaneous pulsatile growth hormone release in male and female premature infants

               J. D. miller (1992)
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                Author and article information

                Journal
                HRE
                Horm Res Paediatr
                10.1159/issn.1663-2818
                Hormone Research in Paediatrics
                S. Karger AG
                978-3-8055-7097-8
                978-3-318-00598-1
                1663-2818
                1663-2826
                2000
                July 2000
                17 November 2004
                : 53
                : Suppl 1
                : 50-54
                Affiliations
                Section Pediatric Endocrinology, University Children’s Hospital Tübingen, Germany
                Article
                53205 Horm Res 2000;53(suppl 1):50–54
                10.1159/000053205
                10895043
                © 2000 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 2, References: 35, Pages: 5
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