Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis.

Abstract

Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied. The aim of this study was to investigate the role of ileal bacteria in modulating local and systemic immune responses in AS.

Journal

Journal ID (iso-abbrev): Ann. Rheum. Dis.

Title: Annals of the rheumatic diseases

Publisher: BMJ

ISSN (Electronic): 1468-2060

ISSN (Print): 0003-4967

Publication date (Electronic): Jun 2017

Volume: 76

Issue: 6

Affiliations

[1 ] Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Reumatologia, University of Palermo, Palermo, Italy.

[2 ] UOC di Anatomia Patologica, Ospedali riuniti villa Sofia-Cervello, Palermo, Italy.

[3 ] Dipartimento di Biopatologia e Biotecnologie Mediche, Università di Palermo, Palermo, Italy.

[4 ] Istituto di Clinica Medica Generale, Ematologia ed Immunologia Clinica, Università Politecnica delle Marche, Ancona, Italy.

[5 ] Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.

[6 ] Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center, Ghent University, Belgium.

[7 ] Department of Rheumatology, Ghent University, Ghent University Hospital, Ghent, Belgium.

[8 ] Division of Rheumatology, Department of Biotechnological and Applied Clinical Science, School of Medicine, University of L'Aquila, L'Aquila, Italy.

[9 ] Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Center for Celiac Research and Treatment, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

Article

Publisher Item ID: annrheumdis-2016-210000

DOI: 10.1136/annrheumdis-2016-210000

PubMed ID: 28069576