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Abstract
Zika virus (ZIKV) outbreak has emerged as a global health threat, particularly in
tropical areas, over the past few years. No antiviral therapy or vaccine is available
at present. For these reasons, repurposing clinically approved drugs against ZIKV
infection may provide rapid and cost-effective global health benefits. Here, we explored
this strategy and screened eight FDA-approved drugs for antiviral activity against
ZIKV using a cell-based assay. Our results show that the antimalarial drug amodiaquine
has anti-ZIKV activity with EC50 at low micromolar concentrations in cell culture.
We further characterized amodiaquine antiviral activity against ZIKV and found that
it targets early events of the viral replication cycle. Altogether, our results suggest
that amodiaquine may be efficacious for the treatment of ZIKV infection.