Molecular Updates in Prostate Cancer.

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Abstract

A wide array of molecular markers and genomic signatures, reviewed in this article, may soon be used as adjuncts to currently established screening strategies, prognostic parameters, and early detection markers. Markers of genetic susceptibility to PCA, recurrent epigenetic and genetic alterations, including ETS gene fusions, PTEN alterations, and urine-based early detection marker PCA3, are discussed. Impact of recent genome-wide assessment on our understanding of key pathways of PCA development and progression and their potential clinical implications are highlighted.

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Journal

Journal ID (iso-abbrev): Surg Pathol Clin

Title: Surgical pathology clinics

Publisher: Elsevier BV

ISSN (Electronic): 1875-9157

ISSN (Print): 1875-9157

Publication date (Electronic): Dec 2015

Volume: 8

Issue: 4

Affiliations

[1 ] Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: gnetto1@jhmi.edu.

Article

Publisher Item ID: S1875-9181(15)00105-1

DOI: 10.1016/j.path.2015.08.003

PubMed ID: 26612215

SO-VID: c61677bd-65e2-4129-9cac-1830dacd5f3e

History

Keywords: Carcinogenesis,Prostate cancer,PCA3,Genomic classification

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Keywords: Carcinogenesis, Prostate cancer, PCA3, Genomic classification

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