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      A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

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      Cell

      Elsevier BV

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          Abstract

          Two cDNAs were isolated whose dimerized products bind specifically to a DNA sequence, kappa E2, located in the immunoglobulin kappa chain enhancer. Both cDNAs share a region of extensive identity to the Drosophila daughterless gene and obvious similarity to a segment in three myc proteins, MyoD, and members of the Drosophila achaete-scute and twist gene family. The homologous regions have the potential to form two amphipathic helices separated by an intervening loop. Remarkable is the stringent conservation of hydrophobic residues present in both helices. We demonstrate that this new motif plays a crucial role in both dimerization and DNA binding.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          March 1989
          March 1989
          : 56
          : 5
          : 777-783
          Article
          10.1016/0092-8674(89)90682-X
          2493990
          c6173d70-418f-4b68-ae1f-3f174126565a
          © 1989

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