The CCR6/CCL20 axis mediates Th17 cell migration to the ocular surface in dry eye disease.

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Abstract

Th17 cells are believed to be the primary effector cells in the pathogenesis of dry eye disease (DED). However, the mechanisms by which Th17 cells migrate from the lymphoid tissues to the ocular surface are unknown. The purpose of this study was to investigate the role of the C-C chemokine receptor 6/C-C chemokine ligand 20 (CCR6/CCL20) chemokine axis in mediating Th17 cell migration in DED.

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Author and article information

Journal

Journal ID (iso-abbrev): Invest. Ophthalmol. Vis. Sci.

Title: Investigative ophthalmology & visual science

Publisher: Association for Research in Vision and Ophthalmology (ARVO)

ISSN (Electronic): 1552-5783

ISSN (Print): 0146-0404

Publication date (Electronic): Jun 12 2013

Volume: 54

Issue: 6

Affiliations

[1 ] Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.

Article

Publisher Item ID: iovs.12-11216

DOI: 10.1167/iovs.12-11216

PMC ID: 3681477

PubMed ID: 23702781

SO-VID: c617a6cc-33aa-4493-801e-b2708a924b73

History

Keywords: CCL20,CCR6,Th17 cell,cell migration,dry eye

Data availability:

Keywords: CCL20, CCR6, Th17 cell, cell migration, dry eye

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