Contributors
Naoko Aizawa: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
ResourcesRole: Writing – original draft
Hiroshi Kunikata: Role: SupervisionRole: Writing – original draft
Yukihiro Shiga: Role: Data curationRole: Formal analysisRole: Investigation
Satoru Tsuda: Role: Data curationRole: Formal analysisRole: Investigation
Yu Yokoyama: Role: Data curationRole: Formal analysisRole: Investigation
Kazuko Omodaka: Role: Data curationRole: Formal analysisRole: Investigation
Tomoki Yasui: Role: Data curationRole: Funding acquisition
Keiichi Kato: Role: Data curationRole: Funding acquisition
Hiroaki Kurashima: Role: ConceptualizationRole: Funding acquisitionRole: Writing – review & editing
Etsuyo Miyamoto: Role: ConceptualizationRole: Funding acquisitionRole: Writing – review & editing
Masayo Hashimoto: Role: ConceptualizationRole: Funding acquisitionRole: Writing – review & editing
Toru Nakazawa:
ORCID: http://orcid.org/0000-0002-5591-4155
Role: ConceptualizationRole: ResourcesRole: SupervisionRole: Writing – review & editing
Gianni Virgili: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
13
December
2017
Publication date Collection: 2017
Volume: 12
Issue: 12
Electronic Location Identifier: e0188692
Affiliations
[1
]
Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai,
Japan
[2
]
Department of Retinal Disease Control, Tohoku University Graduate School of Medicine,
Sendai, Japan
[3
]
Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate
School of Medicine, Sendai, Japan
[4
]
Yasui Eye Clinic, Rifu, Japan
[5
]
Kato Eye Center, Taiwa, Japan
[6
]
Japan Medical Affairs, Global R&D, Santen Pharmaceutical Co. Ltd., Osaka, Japan
[7
]
Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine,
Sendai, Japan
Universita degli Studi di Firenze, ITALY
Author notes
Competing Interests: We have the following interests: The corresponding author, Toru Nakazawa, will be
in charge of implementing the proposed clinical study, with funding from Santen Pharmaceutical
Co. Ltd. In addition, Toru Nakazawa is conducting two other collaborative studies,
with funding from Santen Pharmaceutical Co. Ltd. Toru Nakazawa also serves as a research
consultant to Santen Pharmaceutical Co. Ltd. and is paid by the company. Furthermore,
Tohoku University has received research donations from Santen Pharmaceutical Co. Ltd.
The clinical study was fairly conducted by a study group at Tohoku University. With
regard to conflict of interest with the sponsor companies or other funding sources,
a Committee for Management of Conflict of Interest in Tohoku University has already
reviewed and approved the study. If any additional condition or change in conflict
of interest occurs, the study group reported it to the Committee for Management of
Conflict of Interest in Tohoku University and applied for a review to ensure fairness
regarding conflict of interest with the sponsor companies or other funding sources.
Hiroaki Kurashima, Etsuyo Miyamoto, and Masayo Hashimoto are employees of Santen Pharmaceutical
Co. Ltd. Tomoki Yasui is an employee of Yasui Eye Clinic, and Keiichi Kato is an employee
of Kato Eye Center. There are no patents, products in development or marketed products
to declare. This does not alter our adherence to all the PLOS ONE policies on sharing
data and materials.
Author information
Article
Publisher ID:
PONE-D-17-07455
DOI: 10.1371/journal.pone.0188692
PMC ID: 5728557
PubMed ID: 29236784
SO-VID: c6227e9f-1b21-43d4-aa0e-a31b59a14373
Copyright © © 2017 Aizawa et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 12
May
2017
Date
accepted
: 10
November
2017
Page count
Figures: 3,
Tables: 4,
Pages: 15
Funding
Funded by: Santen Pharmaceutical Co. Ltd.
This study was performed under collaborative research agreement between Tohoku University
Graduate School of Medicine and Santen Pharmaceutical Co. Ltd. and funded by Santen
Pharmaceutical Co., Ltd. Santen Pharmaceutical Co., Ltd. contributed towards study
design and preparation of the manuscript but did not participate in data management,
statistical analysis, or audit which was conducted by Contract Research Organizations.
Hiroaki Kurashima, Etsuyo Miyamoto, and Masayo Hashimoto are employees of Santen Pharmaceutical
Co. Ltd. Tomoki Yasui is an employee of Yasui Eye Clinic, and Keiichi Kato is an employee
of Kato Eye Center. Yasui Eye Clinic and Kato Eye Center provided support in the form
of salaries for authors (TS, KK), but did not have any additional role in the study
design, data collection and analysis, decision to publish, or preparation of the manuscript.
The specific roles of these authors are articulated in the ‘author contributions’
section.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Head
Subject:
Eyes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Head
Subject:
Eyes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Ocular System
Subject:
Eyes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Ocular System
Subject:
Eyes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Flow
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Flow
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Flow
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Flow
Subject:
Medicine and Health Sciences
Subject:
Ophthalmology
Subject:
Eye Diseases
Subject:
Glaucoma
Subject:
Medicine and Health Sciences
Subject:
Ophthalmology
Subject:
Visual Impairments
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Hormones
Subject:
Lipid Hormones
Subject:
Prostaglandin
Subject:
Research and Analysis Methods
Subject:
Mathematical and Statistical Techniques
Subject:
Statistical Methods
Subject:
Regression Analysis
Subject:
Linear Regression Analysis
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Statistics (Mathematics)
Subject:
Statistical Methods
Subject:
Regression Analysis
Subject:
Linear Regression Analysis
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Ocular System
Subject:
Intraocular Pressure
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Ocular System
Subject:
Intraocular Pressure
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Diagnostic Radiology
Subject:
Tomography
Subject:
Research and Analysis Methods
Subject:
Imaging Techniques
Subject:
Diagnostic Radiology
Subject:
Tomography
Subject:
Medicine and Health Sciences
Subject:
Radiology and Imaging
Subject:
Diagnostic Radiology
Subject:
Tomography
Custom metadata
