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      Oxygen Affinity of Erythrocytes and Pulmonary Gas Exchange in Patients on Continuous Ambulatory Peritoneal Dialysis


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          In 11 patients on continuous ambulatory peritoneal dialysis 2,3-diphosphoglycerate, oxygen (O<sub>2</sub>) affinity of red cells (P<sub>50</sub>), blood gases, ventilation, and O<sub>2</sub> consumption were studied. Contrary to patients on maintenance hemodialysis, 2,3-diphosphoglycerate and P<sub>50</sub> were normal in patients on continuous ambulatory peritoneal dialysis; they were correlated with each other. Arterial O<sub>2</sub> pressure was normal; under the conditions of dialysis with 35 mmol lactate per liter dialysis fluid a slight metabolic acidosis persisted; it was combined with a moderate respiratory alkalosis. Position had no influence upon pulmonary gas exchange with the exception of the alveolo-arterial gradient which was elevated when the abdominal cavity was filled with dialysis fluid and the patients assumed the supine position. Ventilation was in the normal range, whereas O<sub>2</sub> consumption was low, possibly due to a reduction in muscle mass in some of the patients. It is concluded that pulmonary gas exchange and erythrocyte O<sub>2</sub> transport were normal and that O<sub>2</sub> requirements tended to be low in this group of patients on continuous ambulatory peritoneal dialysis.

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          Author and article information

          S. Karger AG
          04 December 2008
          : 38
          : 4
          : 248-252
          Department of Medicine, Kantonsspital Aarau, Switzerland
          183317 Nephron 1984;38:248–252
          © 1984 S. Karger AG, Basel

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          : 03 February 1984
          Page count
          Pages: 5
          Original Paper

          Cardiovascular Medicine,Nephrology
          Continuous ambulatory peritoneal dialysis,2,3-Diphosphoglycerate,Oxygen affinity,Pulmonary gas exchange


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