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      Analysis of peptides derived from Pro Atrial Natriuretic Peptide that circulate in man and increase in heart disease

      , , , ,
      Scandinavian Journal of Clinical and Laboratory Investigation
      Informa UK Limited

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          Statistical Methods in Biology

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            The heart and the atrial natriuretic factor.

            The search for natriuretic hormones or factors by studies of negative pressure breathing, atrial distension experiments, head-out water immersion, expansion of blood volume, Na+/K+-ATPase inhibitors and parabiosis experiments in Dahl rats has led to the finding that the atria are a peptide-secreting endocrine gland. This new natriuretic hormone has now been purified, sequenced and synthetized, and its cDNA and gene have been cloned. The native and synthetic hormones exert identical wide ranging effects (possibly through particulate guanylate cyclase stimulation and adenylate cyclase inhibition) on the kidney, blood vessels, adrenal cortex, and pituitary. Physiopathologic implications of the hormone in experimental hypertension, congestive heart failure, and expansion of blood volume are beginning to emerge.
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              Atriopeptins as cardiac hormones

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                Author and article information

                Journal
                Scandinavian Journal of Clinical and Laboratory Investigation
                Scandinavian Journal of Clinical and Laboratory Investigation
                Informa UK Limited
                0036-5513
                1502-7686
                July 08 2009
                January 1998
                July 08 2009
                January 1998
                : 58
                : 3
                : 205-216
                Article
                10.1080/00365519850186599
                c64790a2-b402-4af0-85dc-e6bd6ae219e9
                © 1998
                History

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