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      Autophagy in infection, inflammation, and immunity

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      1 , , 2 , 2
      Nature reviews. Immunology

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          Preface

          Autophagy is a fundamental cell biological pathway affecting immunity. Whereas autophagy is an antimicrobial effector of conventional pattern recognition receptors (PRRs), autophagic adaptors termed SLRs represent a new subset of PRRs and provide the mechanistic basis for autophagic elimination of intracellular microbes. Autophagy controls inflammation via regulatory interactions with innate immunity signalling, by removing endogenous inflammasome agonists, and thorough effects on secretion of immune mediators. Autophagy contributes to antigen presentation, T cell homeostasis, and affects T cell repertories and polarization including Th17 inflammation. Here, we review the above relationships organized into four principal roles of autophagy in infection, inflammation, and immunity.

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          Author and article information

          Journal
          101124169
          27017
          Nat Rev Immunol
          Nat. Rev. Immunol.
          Nature reviews. Immunology
          1474-1733
          1474-1741
          11 January 2017
          October 2013
          07 March 2017
          : 13
          : 10
          : 722-737
          Affiliations
          [1 ]Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA
          [2 ]Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
          Article
          PMC5340150 PMC5340150 5340150 nihpa836047
          10.1038/nri3532
          5340150
          24064518
          c6623ec1-7426-4296-99a7-9bdc95cbdb9b
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