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      Translating Germline Cancer Risk into Precision Prevention.

      1 , 2 , 3
      Cell
      Elsevier BV

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          Abstract

          Study of the biology of tumors caused by germline mutations has led to recent paradigm-changing therapy and is driving precision prevention efforts, including immune oncology and early detection research. Here, we explore recent biologic advances that are redefining the spectrum of cancers linked to various hereditary predisposition syndromes and can be leveraged to improve personalized risk assessment and develop novel interventions to prevent or intercept cancer.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          1097-4172
          0092-8674
          Feb 09 2017
          : 168
          : 4
          Affiliations
          [1 ] Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.
          [2 ] QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia.
          [3 ] Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: slippman@ucsd.edu.
          Article
          S0092-8674(17)30116-2
          10.1016/j.cell.2017.01.031
          28187278
          c662b259-081c-4a5c-9198-a1edca3a043f
          History

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