4
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid Films

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The optimization of bilayer coverage on particles is important for a variety of biomedical applications, such as drug, vaccine, and genetic material delivery. This work aims at optimizing the deposition of cationic bilayers on silica over a range of experimental conditions for the intervening medium and two different assemblies for the cationic lipid, namely, lipid films or pre-formed lipid bilayer fragments. The lipid adsorption on silica in situ over a range of added lipid concentrations was determined from elemental analysis of carbon, hydrogen, and nitrogen and related to the colloidal stability, sizing, zeta potential, and polydispersity of the silica/lipid nanoparticles. Superior bilayer deposition took place from lipid films, whereas adsorption from pre-formed bilayer fragments yielded limiting adsorption below the levels expected for bilayer adsorption.

          Related collections

          Most cited references36

          • Record: found
          • Abstract: found
          • Article: not found

          Adsorption of organic molecules on silica surface.

          The adsorption behaviour of various organic adsorbates on silica surface is reviewed. Most of the structural information on silica is obtained from IR spectral data and from the characteristics of water present at the silica surface. Silica surface is generally embedded with hydroxy groups and ethereal linkages, and hence considered to have a negative charged surface prone to adsorption of electron deficient species. Adsorption isotherms of the adsorbates delineate the nature of binding of the adsorbate with silica. Aromatic compounds are found to involve the pi-cloud in hydrogen bonding with silanol OH group during adsorption. Cationic and nonionic surfactants adsorb on silica surface involving hydrogen bonding. Sometimes, a polar part of the surfactants also contributes to the adsorption process. Styryl pyridinium dyes are found to anchor on silica surface in flat-on position. On modification of the silica by treating with alkali, the adsorption behaviour of cationic surfactant or polyethylene glycol changes due to change in the characteristics of silica or modified silica surface. In case of PEG-modified silica, adsolubilization of the adsorbate is observed. By using a modified adsorption equation, hemimicellization is proposed for these dyes. Adsorptions of some natural macromolecules like proteins and nucleic acids are investigated to study the hydrophobic and hydrophilic binding sites of silica. Artificial macromolecules like synthetic polymers are found to be adsorbed on silica surface due to the interaction of the multifunctional groups of the polymers with silanols. Preferential adsorption of polar adsorbates is observed in case of adsorbate mixtures. When surfactant mixtures are considered to study competitive adsorption on silica surface, critical micelle concentration of individual surfactant also contributes to the adsorption isotherm. The structural study of adsorbed surface and the thermodynamics of adsorption are given some importance in this review.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Nanoengineered silica: Properties, applications and toxicity

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery.

              The advent of nanotechnology has revolutionized drug delivery in terms of improving drug efficacy and safety. Both polymer-based and lipid-based drug-loaded nanocarriers have demonstrated clinical benefit to date. However, to address the multifaceted drug delivery challenges ahead and further expand the spectrum of therapeutic applications, hybrid lipid-polymer nanocomposites have been designed to merge the beneficial features of both polymeric drug delivery systems and liposomes in a single nanocarrier. This review focuses on different classes of nanohybrids characterized by a drug-loaded polymeric matrix core enclosed in a lipid shell. Various nanoengineering approaches to obtain lipid-polymer nanocomposites with a core-shell nanoarchitecture will be discussed as well as their predominant applications in drug delivery.
                Bookmark

                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Biomimetics (Basel)
                Biomimetics (Basel)
                biomimetics
                Biomimetics
                MDPI
                2313-7673
                20 October 2017
                December 2017
                : 2
                : 4
                : 20
                Affiliations
                Biocolloids Laboratory, Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, São Paulo 05508-000, SP, Brazil; rodrigo@ 123456iq.usp.br (R.T.R.); victor.hugo.braga@ 123456usp.br (V.H.A.B.)
                Author notes
                [* ]Correspondence: amcr@ 123456usp.br ; Tel.: +55-011-3091-1887
                Author information
                https://orcid.org/0000-0002-5099-4256
                https://orcid.org/0000-0001-8500-2707
                Article
                biomimetics-02-00020
                10.3390/biomimetics2040020
                6352667
                c667aa12-7f1c-4d73-b433-65367783a95a
                © 2017 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 10 August 2017
                : 18 October 2017
                Categories
                Article

                aerosil ox-50,dioctadecyldimethylammonium bromide,n-[1-(2,3-dioleoyloxy)propyl]-n,n,n-trimethylammonium chloride,elemental analysis for in situ adsorption,colloidal stability,cationic bilayer fragments,films of cationic lipids,optimal bilayer adsorption from films

                Comments

                Comment on this article