Hyperleptinemia Is Not Responsible for Decreased Paraoxonase Activity in Hemodialysis Patients

Abstract

Background: Exogenous leptin markedly decreased plasma paraoxonase (PON1) activity in rats. Hyperleptinemia and decreased PON1 activity have previously been demonstrated in uremia. Therefore, we investigated the relationship between leptin level and PON1 activity in hemodialysis (HD) patients. Methods: Leptin and PON1 were determined in 40 HD patients and 40 age-matched controls with similar body mass index (BMI). Results: Leptin was higher (p < 0.001) and PON1 activity was lower (p < 0.001) in HD patients than in controls. PON1 and PON1/HDL ratio was higher in HD patients with BMI >25 kg/m² than in HD patients with BMI <25 kg/m². It was not due to a difference in frequency of high activity phenotype of PON1 among subgroups of HD patients. There was no similar difference in controls. Spearman analysis showed a significant correlation between leptin and PON1 activity (p < 0.02), BMI (p < 0.001), triglyceride (TG) (p < 0.03), and Kt/V (–0.323, p < 0.03), but multiparametric regression analysis did not reveal it. PON1 activity depended on BMI in both models. In controls, leptin correlated with BMI (p < 0.001) and TG (p < 0.002) but not PON1 activity. A slight decrease in leptin concentration and PON1 activity during HD was observed. Conclusion: Our results suggest the role of other pathophysiological conditions besides hyperleptinemia resulting in decreased PON1 activity in HD patients.

Journal

Journal ID (publisher-id): NEC

Journal ID (nlm-ta): Nephron Clin Pract

Journal ID (doi): 10.1159/issn.1660-2110

Title: Nephron Clinical Practice

Publisher: S. Karger AG

ISSN (Electronic): 1660-2110

Publication date Subscription-year: 2006

Publication date (Print): June 2006

Publication date (Electronic): 13 March 2006

Volume: 103

Issue: 3

Pages: c114-c120

Affiliations

Divisions of ^aNephrology and ^bMetabolism, 1st Department of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary

Article

Publisher ID: 92020 Other ID: Nephron Clin Pract 2006;103:c114–c120

DOI: 10.1159/000092020

PubMed ID: 16534235

Copyright statement: © 2006 S. Karger AG, Basel

License:

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Page count

Figures: 2, Tables: 6, References: 22, Pages: 1

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Categories

Subject: Original Paper