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      Pathogen Recognition and Innate Immunity

      , ,
      Cell
      Elsevier BV

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          Abstract

          Microorganisms that invade a vertebrate host are initially recognized by the innate immune system through germline-encoded pattern-recognition receptors (PRRs). Several classes of PRRs, including Toll-like receptors and cytoplasmic receptors, recognize distinct microbial components and directly activate immune cells. Exposure of immune cells to the ligands of these receptors activates intracellular signaling cascades that rapidly induce the expression of a variety of overlapping and unique genes involved in the inflammatory and immune responses. New insights into innate immunity are changing the way we think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          February 2006
          February 2006
          : 124
          : 4
          : 783-801
          Article
          10.1016/j.cell.2006.02.015
          16497588
          c6a3a0fd-2308-4256-9d38-5aa98ce650c6
          © 2006

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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