Cross-sectional study was conducted on 774 students from a Syrian University using questionnaire to estimate the prevalence of smoking among University students and to identify factors related to smoking. Smoking prevalence was 20.75%. Mean age (years) of smokers (25 ± 2.2) was significantly older than non-smokers (21 ± 1.8). Smoking prevalence among males was 26.1%, significantly higher than among females (9.5%). Female students consumed significantly higher number of cigarettes /day ( 21 ± 5) than the male (9 ± 2). Smoking was significantly higher (27.8%) among students living away from their families than (16.2%) those living with families. Keywords: smoking, risk factors, youth © 2017. The Authors. Published for AMER ABRA by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.