0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Simultaneous Plasma and Saliva Steroid Measurements as an Index of Control in Congenital Adrenal Hyperplasia (CAH)

      ,

      Hormone Research in Paediatrics

      S. Karger AG

      Congenital adrenal hyperplasia, Adrenal steroids, Saliva, Growth

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A detailed study involving simultaneous measurements of plasma and saliva 17OH-progesterone (17OHP), and plasma testosterone concentrations was performed at frequent intervals over a 3-year period in 16 patients with congenital adrenal hyperplasia (CAH). There was a close correlation between the results of these three biochemical measurements over a wide range of concentrations. The practical application of a sensitive saliva 17OHP radioimmunoassay permitted detailed monitoring of patients receiving various glucocorticoid preparations through repeated frequent saliva sampling over the whole day. When the results of serial steroid measurements were analysed in relation to growth velocity in prepubertal patients, it was possible to devise upper limits of 40 nmol/l, 0.8 nmol/l and 1,500 pmol/l for plasma 17OHP, plasma testosterone and saliva 17OHP concentrations, respectively, in well-controlled patients. Applying these guidelines from the early onset of treatment should ensure normal growth potential in treated CAH children, at least until puberty.

          Related collections

          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1982
          1982
          25 November 2008
          : 16
          : 3
          : 142-150
          Affiliations
          Department of Child Health and Tenovus Institute, Welsh National School of Medicine, Cardiff, UK
          Article
          179495 Horm Res 1982;16:142–150
          10.1159/000179495
          7106699
          © 1982 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Paper

          Comments

          Comment on this article