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Abstract
Human butyrylcholinesterase (BChE, EC 3.1.1.8) or acetylcholinesterase (AChE, EC 3.1.1.7)
from fetal bovine serum (FBS), administered i.v. in mice, sequestered at approximately
1:1 stoichiometry the highly toxic anti-ChE organophosphate, 1,2,2-trimethylpropyl
methyl-fluorophosphonate (soman). A quantitative linear correlation was demonstrated
between blood-ChE levels and the protection conferred by exogeneously administered
ChE. Results presented here demonstrate that either human BChE or FBS-AChE is an effective
prophylactic measure sufficient to protect mice from multiple LD50S of soman without
the administration of post-treatment supportive drugs.