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      Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.

      1 ,
      Annual review of genetics
      Annual Reviews

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          Abstract

          Completion of the cell cycle requires the temporal and spatial coordination of chromosome segregation with mitotic spindle disassembly and cytokinesis. In budding yeast, the protein phosphatase Cdc14 is a key regulator of these late mitotic events. Here, we review the functions of Cdc14 and how this phosphatase is regulated to accomplish the coupling of mitotic processes. We also discuss the function and regulation of Cdc14 in other eukaryotes, emphasizing conserved features.

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          Author and article information

          Journal
          Annu Rev Genet
          Annual review of genetics
          Annual Reviews
          0066-4197
          0066-4197
          2004
          : 38
          Affiliations
          [1 ] Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. frankste@mit.edu
          Article
          10.1146/annurev.genet.38.072902.093051
          15568976
          c6eca038-0bdc-4508-a8dc-6f49e362e9ea
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