Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background

Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive and little is known about the independent association between recreational physical inactivity and EOC risk. We conducted a pooled analysis of nine studies from the Ovarian Cancer Association Consortium (OCAC) to investigate the association between chronic recreational physical inactivity and EOC risk.

Methods

In accordance with the 2008 Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. Multivariable logistic regression was utilized to estimate the odds ratios (OR) and 95% confidence intervals (CI) for the association between inactivity and EOC risk overall and by subgroups based upon histotype, menopausal status, race and body mass index (BMI).

Results

The current analysis included data from 8,309 EOC patients and 12,612 controls. We observed a significant positive association between inactivity and EOC risk (OR=1.34, 95% CI: 1.14-1.57) and similar associations were observed for each histotype.

Conclusions

In this large pooled analysis examining the association between recreational physical inactivity and EOC risk, we observed consistent evidence of an association between chronic inactivity and all EOC histotypes.

Impact

These data add to the growing body of evidence suggesting that inactivity is an independent risk factor for cancer. If the apparent association between inactivity and EOC risk is substantiated, additional work via targeted interventions should be pursued to characterize the dose of activity required to mitigate the risk of this highly fatal disease.

Related collections

Author and article information

Contributors

Susan Jordan: On behalf of : on behalf of The Australian Ovarian Cancer Study Group

Journal

Journal ID (nlm-journal-id): 9200608

Journal ID (pubmed-jr-id): 2299

Journal ID (nlm-ta): Cancer Epidemiol Biomarkers Prev

Journal ID (iso-abbrev): Cancer Epidemiol. Biomarkers Prev.

Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

ISSN (Print): 1055-9965

ISSN (Electronic): 1538-7755

Publication date Nihms-submitted: 6 May 2016

Publication date (Electronic): 06 May 2016

Publication date (Print): July 2016

Publication date PMC-release: 01 July 2017

Volume: 25

Issue: 7

Pages: 1114-1124

Affiliations

[1 ]Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA

[2 ]Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo NY, USA

[3 ]Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA

[4 ]Department of Biostatistics & Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY, USA

[5 ]Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA

[6 ]Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany and University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany

[7 ]Department of Gynecology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany

[8 ]Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Niedersachsen, Germany

[9 ]Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA

[10 ]Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA

[11 ]Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

[12 ]Department of Epidemiology, The Geisel School of Medicine at Dartmouth Medical, Hanover, NH, USA

[13 ]Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

[14 ]Ovarian Cancer Center of Excellence, Women’s Cancer Research Program, Magee-Women’s Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

[15 ]Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, KS, USA

[16 ]Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA

[17 ]Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA

[18 ]Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark

[19 ]Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark

[20 ]Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan

[21 ]Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

[22 ]Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane Qld, Australia

[23 ]Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

[24 ]Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan

[25 ]The University of Texas School of Public Health, Houston, TX, USA

[26 ]Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY, USA

[27 ]Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA

[28 ]Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

[29 ]Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA

[30 ]Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA

[31 ]Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA

[32 ]Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA

[33 ]Department of Public Health Sciences, The University of Virginia, Charlottesville, VA, USA

[34 ]Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA

Author notes

Corresponding author: Dr. Kirsten B. Moysich, Department of Cancer Prevention and Control, Roswell Park Cancer Institute, 352 Carlton House, Elm and Carlton Streets, Buffalo, NY 14263, Phone: 716-845-8004, Fax: 716-845-1126, Kirsten.moysich@ 123456roswellpark.org

Article

Accession ID: PMC4930728 Pmcid ID: PMC4930728 Pmc-uid ID: 4930728 Manuscript ID: nihpa783951

DOI: 10.1158/1055-9965.EPI-15-1330

PMC ID: 4930728

PubMed ID: 27197285

SO-VID: c6f11823-b456-4687-a90d-132787aa1725

History

Comments

Comment on this article

scite_

Cited by 12

See all cited by

- Version 1