Cu-Mediated Ullmann-Type Cross-Coupling and Industrial Applications in Route Design, Process Development, and Scale-up of Pharmaceutical and Agrochemical Processes

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Cross-coupling reactions of organoboranes: an easy way to construct C-C bonds (Nobel Lecture).

Akira Suzuki (2011)

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Palladium-catalyzed cross-coupling: a historical contextual perspective to the 2010 Nobel Prize.

Carin Johansson Seechurn, Matthew Kitching, Thomas J Colacot … (2012)

In 2010, Richard Heck, Ei-ichi Negishi, and Akira Suzuki joined the prestigious circle of Nobel Laureate chemists for their roles in discovering and developing highly practical methodologies for C-C bond construction. From their original contributions in the early 1970s the landscape of the strategies and methods of organic synthesis irreversibly changed for the modern chemist, both in academia and in industry. In this Review, we attempt to trace the historical origin of these powerful reactions, and outline the developments from the seminal discoveries leading to their eminent position as appreciated and applied today. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Copper-mediated coupling reactions and their applications in natural products and designed biomolecules synthesis.

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Author and article information

Contributors

Qiang Yang: (View ORCID Profile)

Dawei Ma: (View ORCID Profile)

Journal

Title: Organic Process Research & Development

Abbreviated Title: Org. Process Res. Dev.

Publisher: American Chemical Society (ACS)

ISSN (Print): 1083-6160

ISSN (Electronic): 1520-586X

Publication date Created: June 17 2022

Publication date (Electronic): May 24 2022

Publication date (Print): June 17 2022

Volume: 26

Issue: 6

Pages: 1690-1750

Affiliations

[1 ]Synthetic Molecule Design and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States

[2 ]Department of Chemistry, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China

[3 ]State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China