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      The genetics of Caenorhabditis elegans.

      Genomics

      Sex Chromosomes, Reproduction, Recombination, Genetic, Phenotype, Nervous System Physiological Phenomena, physiology, drug effects, Nematoda, Mutation, Movement, pharmacology, Mesylates, Male, Genetics, Behavioral, Genetic Linkage, Genetic Complementation Test, Genes, Lethal, Female, Crosses, Genetic, Chromosome Mapping, Animals

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          Abstract

          Methods are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm. About 300 EMS-induced mutants affecting behavior and morphology have been characterized and about one hundred genes have been defined. Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large.

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          Author and article information

          Journal
          10.1002/cbic.200300625
          1213120
          4366476

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