The relationship of autophagy defects to cartilage damage during joint aging in a mouse model.

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Abstract

Aging is a main risk factor for osteo arthritis (OA), the most prevalent musculoskeletal disorder. Defects in autophagy, an essential cellular homeostasis mechanism, have recently been observed in OA articular cartilage. The objectives of this study were to establish the constitutive level of autophagy activation in normal cartilage and to monitor the temporal relationship between changes in autophagy and aging-related degradation of cartilage in a mouse model.

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Journal

Journal ID (iso-abbrev):

Title: Arthritis & rheumatology (Hoboken, N.J.)

Publisher: Wiley-Blackwell

ISSN (Electronic): 2326-5205

ISSN (Print): 2326-5191

Publication date (Electronic): Jun 2015

Volume: 67

Issue: 6

Affiliations

[1 ] The Scripps Research Institute La Jolla California and Instituto de Investigación Biomédica de A Coruña Complexo Hospitalario Universitario de A Coruña SERGAS and Universidade da Coruña, A Coruña, Spain.

[2 ] The Scripps Research Institute, La Jolla, California.

Article

Mid ID: NIHMS668464

DOI: 10.1002/art.39073

PMC ID: 4446178

PubMed ID: 25708836

SO-VID: c70b11c2-2a2f-4e43-96e7-bd1eee7f7e1a

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