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A vaginal fluid simulant
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Abstract
A fluid medium was developed to simulate the fluid produced in the human vagina. The
composition of the medium was based on an extensive review of the literature on constituents
of human vaginal secretions. In choosing the ingredients for this medium, the goal
was to emphasize properties that influence interactions of vaginal fluid with topical
contraceptive, prophylactic, or therapeutic products. Among these properties, pH and
osmolarity play a dominant role in physicochemical processes that govern drug release
and distribution.