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      Renaissance in antibacterial discovery from actinomycetes.

      Current Opinion in Pharmacology
      Elsevier BV

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          Abstract

          The soil actinomycetes have been important sources of antibiotics, but were nearly abandoned in recent years in favor of high-throughput target-based screening of chemical libraries. The latter approach has not been productive, so it is time to reinvigorate the discovery of new antibiotics from a proven source. Recent progress has been made on antibiotic discovery from actinomycetes by using high-throughput fermentation, isolation of marine actinomycetes, mining genomes for cryptic pathways, and combinatorial biosynthesis to generate new secondary metabolites related to existing pharmacophores.

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          18524678
          10.1016/j.coph.2008.04.008

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