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Abstract
In 2030, one in five Americans will be older than 65 years, and with that an increase
in the number of individuals who experience loss in cognitive capacity is to be expected.
At the same time, nutrition within the first 1000 days postconception has been suggested
to strongly influence cognitive outcomes across the life-span in humans. Eggs are
a primary source of both choline and the xanthophyll carotenoid lutein in the western
diet, and both have been suggested to influence cognitive function in humans. This
comprehensive review critically examines the effects of eggs, choline, and lutein
on cognition across the life-span. There seems to be clear scientific evidence to
suggest that both choline and lutein play a vital role in brain and neurological development
during the first 1000 days postconception. The extent to which higher intakes of choline
have the potential to enhance or influence cognition during childhood, adulthood,
and/or age-related cognitive decline needs further investigation. Emerging but consistent
research suggests that lutein has the potential to influence cognition across the
life-span and that sufficient intakes during mid to late adulthood may help to ward
off age-related cognitive decline. Macular pigment optical density (MPOD) seems to
be a reliable and consistent biomarker of brain lutein concentrations across the life-span
and potentially one for clinically assessing cognitive status. This review summarizes
the current peer-reviewed literature and existing gaps in research.