Transcript Levels of Androgen Receptor Variant 7 and Ubiquitin-Conjugating Enzyme 2C in Hormone Sensitive Prostate Cancer and Castration-Resistant Prostate Cancer.

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Abstract

This study is designed to identify the androgen receptor variant 7 (AR-V7) status, clinical significance of AR-V7 in hormone sensitive prostate cancer (HSPC). Then, we evaluated AR-V7 and changes of its target gene, ubiquitin-conjugating enzyme E2C (UBE2C) which is an anaphase-promoting complex/cyclosome (APC/C)-specific ubiquitin-conjugating enzyme, in castration-resistant prostate cancer (CRPC) in serial tumor biopsies from patients receiving androgen deprivation therapy.

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Author and article information

Journal

Journal ID (iso-abbrev): Prostate

Title: The Prostate

Publisher: Wiley

ISSN (Electronic): 1097-0045

ISSN (Print): 0270-4137

Publication date (Electronic): January 2017

Volume: 77

Issue: 1

Affiliations

[1 ] Department of Urology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea.

[2 ] Department of Pharmacology, Pusan National University School of Medicine, Yangsan, Republic of Korea.

[3 ] Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

[4 ] Biomedical Research Institute, Pusan National University School of Medicine, Busan, Republic of Korea.

Article

DOI: 10.1002/pros.23248

PubMed ID: 27550197

SO-VID: c733d0b1-2501-4797-82b6-82fbfa9bbf2e

History

Keywords: androgen receptor,castration-resistant prostate cancer,UBE2C

Data availability:

Keywords: androgen receptor, castration-resistant prostate cancer, UBE2C

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