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      The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes.

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          Abstract

          The prediction of the quaternary structure of biomolecular macromolecules is of paramount importance for fundamental understanding of cellular processes and drug design. In the era of integrative structural biology, one way of increasing the accuracy of modeling methods used to predict the structure of biomolecular complexes is to include as much experimental or predictive information as possible in the process. This has been at the core of our information-driven docking approach HADDOCK. We present here the updated version 2.2 of the HADDOCK portal, which offers new features such as support for mixed molecule types, additional experimental restraints and improved protocols, all of this in a user-friendly interface. With well over 6000 registered users and 108,000 jobs served, an increasing fraction of which on grid resources, we hope that this timely upgrade will help the community to solve important biological questions and further advance the field. The HADDOCK2.2 Web server is freely accessible to non-profit users at http://haddock.science.uu.nl/services/HADDOCK2.2.

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          Author and article information

          Journal
          J. Mol. Biol.
          Journal of molecular biology
          1089-8638
          0022-2836
          Feb 22 2016
          : 428
          : 4
          Affiliations
          [1 ] Bijvoet Center for Biomolecular Research, Faculty of Science Department of Chemistry, Utrecht University, Domplein 29, 3512 JE Utrecht, the Netherlands.
          [2 ] Centre National de la Recherche Scientifique Laboratoire d'Informatique pour la Mécanique et les Sciences de l'Ingénieur, rue John Von Neumann, 91403 Orsay, France.
          [3 ] Instaclustr Level 5, 1 Moore Street, Canberra ACT 2600, Australia.
          [4 ] European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
          [5 ] Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.
          [6 ] Faculty of Sciences, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, the Netherlands.
          [7 ] Physik-Department, Technische Universität München, James-Franck-Strasse 1, 85748 Garching, Germany.
          Article
          S0022-2836(15)00537-9
          10.1016/j.jmb.2015.09.014
          26410586
          c748f192-0d31-4eaf-9034-9f07e27c49c9
          Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
          History

          biomolecular docking,data-driven,grid computing,hybrid modeling,protein complexes

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