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      Histone core modifications regulating nucleosome structure and dynamics.

      1 , 2

      Nature reviews. Molecular cell biology

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          Abstract

          Post-translational modifications of histones regulate all DNA-templated processes, including replication, transcription and repair. These modifications function as platforms for the recruitment of specific effector proteins, such as transcriptional regulators or chromatin remodellers. Recent data suggest that histone modifications also have a direct effect on nucleosomal architecture. Acetylation, methylation, phosphorylation and citrullination of the histone core may influence chromatin structure by affecting histone-histone and histone-DNA interactions, as well as the binding of histones to chaperones.

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          Author and article information

          Journal
          Nat. Rev. Mol. Cell Biol.
          Nature reviews. Molecular cell biology
          1471-0080
          1471-0072
          Nov 2014
          : 15
          : 11
          Affiliations
          [1 ] Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK; and the Max Planck Research Group 'Chromatin and Ageing', Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany.
          [2 ] Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK.
          Article
          nrm3890
          10.1038/nrm3890
          25315270

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