Contrast Sensitivity and Spherical Aberration in Eyes Implanted with AcrySof IQ and AcrySof Natural Intraocular Lens: the Results of a Meta-Analysis

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Abstract

Background

To systematically evaluate the visual performance of aspheric AcrySof IQ and spherical AcrySof Natural intraocular lens (IOL) after cataract surgery.

Methodology/Principal Findings

Potential randomized controlled trials (RCTs) that involved implanting AcrySof IQ and AcrySof Natural were searched from PubMed, Web of science, EMBASE, Chinese Science and Technology Periodicals Databases and Cochrane Central Register of Controlled Trials. The methodological quality of the studies was assessed by the Jadad method. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) of best-corrected visual acuity (BCVA), contrast sensitivity and spherical aberration were pooled using a random-effects model. Seven studies were identified and analyzed to compare AcrySof IQ (236 eyes) with AcrySof Natural (232 eyes) after phacoemulsification. There was no significant difference in postoperative BCVA between AcrySof IQ and AcrySof Natural ( p =0.137) after a follow up of 3 months. For contrast sensitivity, these differences reached statistical significance under photopic conditions at two spatial frequencies (3 cycles per degree (cpd), 6 cpd, 12 cpd, and 18 cpd; p =0.022, p =0.017, p = 0.065, and p=0.191, respectively) and under mesopic conditions at three spatial frequencies (3 cpd, 6 cpd, 12 cpd, and 18 cpd; p =0.007, p =0.033, p =0.030, and p =0.080, respectively). Eyes with AcrySof IQ also had statistically significant less spherical aberration than eyes with AcrySof Natural ( p<0.001). Sensitivity analysis showed that the results were relatively stable and reliable.

Conclusions/Significance

The overall findings indicate that AcrySof IQ with a modified aspheric surface induced significantly less spherical aberration than AcrySof Natural. Contrast sensitivity in eyes with AcrySof IQ is better than that in eyes with AcrySof Natural, especially under mesopic conditions.

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Most cited references 29

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Global data on visual impairment in the year 2002.

Serge Resnikoff, Donatella Pascolini, Daniel Etya'ale … (2004)

This paper presents estimates of the prevalence of visual impairment and its causes in 2002, based on the best available evidence derived from recent studies. Estimates were determined from data on low vision and blindness as defined in the International statistical classification of diseases, injuries and causes of death, 10th revision. The number of people with visual impairment worldwide in 2002 was in excess of 161 million, of whom about 37 million were blind. The burden of visual impairment is not distributed uniformly throughout the world: the least developed regions carry the largest share. Visual impairment is also unequally distributed across age groups, being largely confined to adults 50 years of age and older. A distribution imbalance is also found with regard to gender throughout the world: females have a significantly higher risk of having visual impairment than males. Notwithstanding the progress in surgical intervention that has been made in many countries over the last few decades, cataract remains the leading cause of visual impairment in all regions of the world, except in the most developed countries. Other major causes of visual impairment are, in order of importance, glaucoma, age-related macular degeneration, diabetic retinopathy and trachoma.

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A new intraocular lens design to reduce spherical aberration of pseudophakic eyes.

Jack Holladay, Patricia A Piers, Gabor Koranyi … (2015)

The aim of this study was to design and evaluate in the laboratory a new intraocular lens (IOL) intended to provide superior ocular optical quality by reducing spherical aberration. Corneal topography measurements were performed on 71 cataract patients using an Orbscan I. The measured corneal surface shapes were used to determine the wavefront aberration of each cornea. A model cornea was then designed to reproduce the measured average spherical aberration. This model cornea was used to design IOLs having a fixed amount of negative spherical aberration that partially compensates for the average positive spherical aberration of the cornea. Theoretical and physical eye models were used to assess the expected improvement in optical quality of an eye implanted with this lens. Measurements of optical quality provided evidence that if this modified prolate IOL was centered within 0.4 mm and tilted less than 7 degrees, it would exceed the optical performance of a conventional spherical IOL. This improvement occurred without an apparent loss in depth of focus. A new IOL with a prolate anterior surface, designed to partially compensate for the average spherical aberration of the cornea, is intended to improve the ocular optical quality of pseudophakic patients.

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The importance of measuring contrast sensitivity in cases of visual disturbance.

G B Arden (1978)

A description is given of a practical clinical test of contrast sensitivity and of the results obtained on a normal population. An account is given of recent physiological work which illustrates the potential usefulness of the method in ophthalmology, and the clinical results obtained by the author and others are summarised.

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Author and article information

Contributors

Demetrios Vavvas: Role: Editor

Journal

Journal ID (nlm-ta): PLoS One

Journal ID (iso-abbrev): PLoS ONE

Journal ID (publisher-id): plos

Journal ID (pmc): plosone

Title: PLoS ONE

Publisher: Public Library of Science (San Francisco, USA )

ISSN (Electronic): 1932-6203

Publication date Collection: 2013

Publication date (Electronic): 18 October 2013

Volume: 8

Issue: 10

Electronic Location Identifier: e77860

Affiliations

[1 ]Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China

[2 ]Eye Hospital of China Medical University, Shenyang, People’s Republic of China

[3 ]Key Lens Research Laboratory of Liaoning Province, Shenyang, People’s Republic of China

[4 ]School of Public Health, China Medical University, Shenyang, People’s Republic of China

Massachusetts Eye & Ear Infirmary, Harvard Medical School, United States of America

Author notes

* E-mail: ZhangJS_CMU@ 123456163.com

Competing Interests: The authors have declared that no competing interests exist.

Conceived and designed the experiments: JPL JSZ GCL. Performed the experiments: JPL JYZ DW. Analyzed the data: JPL LWM JSZ DW. Contributed reagents/materials/analysis tools: JPL GCL LWM JSZ. Wrote the manuscript: JPL LWM JYZ.

Article

Publisher ID: PONE-D-13-27926

DOI: 10.1371/journal.pone.0077860

PMC ID: 3799620

PubMed ID: 24205001

SO-VID: c74c3f33-629e-4584-846d-8cc048b397ff

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

History

Date received : 2 July 2013

Date accepted : 4 September 2013

Funding

Funding came from the China Natural Science Project to JSZ(81270988). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Contrast Sensitivity and Spherical Aberration in Eyes Implanted with AcrySof IQ and AcrySof Natural Intraocular Lens: the Results of a Meta-Analysis

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Abstract

Background

Methodology/Principal Findings

Conclusions/Significance

Related collections

PLOS Climate

Most cited references 29

Global data on visual impairment in the year 2002.

A new intraocular lens design to reduce spherical aberration of pseudophakic eyes.

The importance of measuring contrast sensitivity in cases of visual disturbance.

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