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      Sulfhydryl Groups in Individual Normal and Nuclear-Cataractous Human Eye Lenses

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          Evaluation of sulfhydryl data derived from the nucleus and cortex of individual human lenses, ranging in age from 40 to 90 years, revealed the following: (a) no significant correlation between the age and the sulfhydryl content of normal and nuclear-cataractous lenses; (b) a significant relationship between the distribution of non-protein-bound sulfhydryl compounds among the lens parts and both age and cataractous state; (c) no significant difference in sulfhydryl data from the cortex between groups of cataractous lenses with increasing nuclear color; and (d) a significant difference in nuclear protein sulfhydryl content between the groups of lenses, varying in cataractous state. If lens parts are separated on the basis of cataract localization, sulfhydryl oxidation in nuclear cataractogenesis seems to be confined to the colored nuclear region. It is suggested that nuclear cataract develops from the inner nucleus towards the cortex of the lens.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 12
          : 2
          : 118-127
          Department of Biochemistry, University of Nijmegen, Nijmegen, and Eye Clinic, Free University of Berlin, Berlin
          265070 Ophthalmic Res 1980;12:118–127
          © 1980 S. Karger AG, Basel

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          Pages: 10
          Original Paper


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