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      The modulatory actions of dopamine D2/3 agonists and antagonists on the locomotor-activating effects of morphine and caffeine in mice

      Pharmacology Biochemistry and Behavior
      Elsevier BV

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          Abstract

          Morphine produces robust increases in locomotor activity in mice. Recent data indicate that dopamine (DA) D2/3 agonists attenuate the discriminative stimulus and antinociceptive effects of mu opioid agonists such as morphine. The present study was designed to determine the extent to which D2/3 receptor activation and blockade can modulate morphine-induced locomotion using a novel cumulative dosing procedure in Swiss-Webster mice. The results indicate that morphine-induced locomotion is nonsignificantly attenuated by the D2/3 agonists quinelorane and quinpirole, whereas the D2/3 antagonists eticlopride and nafadotride, as well as the partial D2/3 agonist BP897, significantly reduced morphine-induced locomotion. To determine the specificity of this modulation, these agonists and antagonists were examined in combination with caffeine, a drug that also indirectly alters DAergic activity. Unlike the effects on morphine, caffeine-induced locomotion was unaltered by eticlopride, nafadotride and BP897, but was attenuated by quinelorane and quinpirole. These results indicate that modulation of D2/3 receptors can, in turn, alter the locomotor-activating effects of morphine.

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          Author and article information

          Journal
          Pharmacology Biochemistry and Behavior
          Pharmacology Biochemistry and Behavior
          Elsevier BV
          00913057
          May 2003
          May 2003
          : 75
          : 2
          : 363-371
          Article
          10.1016/S0091-3057(03)00090-X
          12873628
          c74fb7d5-4ddf-4bd5-b418-55f6a02358a3
          © 2003

          https://www.elsevier.com/tdm/userlicense/1.0/

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