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      Molecular aspects of bacterial pH sensing and homeostasis.

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          Abstract

          Diverse mechanisms for pH sensing and cytoplasmic pH homeostasis enable most bacteria to tolerate or grow at external pH values that are outside the cytoplasmic pH range they must maintain for growth. The most extreme cases are exemplified by the extremophiles that inhabit environments with a pH of below 3 or above 11. Here, we describe how recent insights into the structure and function of key molecules and their regulators reveal novel strategies of bacterial pH homeostasis. These insights may help us to target certain pathogens more accurately and to harness the capacities of environmental bacteria more efficiently.

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          Author and article information

          Journal
          Nat Rev Microbiol
          Nature reviews. Microbiology
          Springer Science and Business Media LLC
          1740-1534
          1740-1526
          May 2011
          : 9
          : 5
          Affiliations
          [1 ] Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA. terry.krulwich@mssm.edu
          Article
          nrmicro2549 NIHMS345141
          10.1038/nrmicro2549
          3247762
          21464825
          c7520e1c-a40c-4d9f-a8ad-f11fb5d3f199
          History

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